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2018年特聘副研究员—孙慧涌

来源: 未知   发布者: 人事处   访问次数: 10 发布日期: 2018-07-16



孙慧涌,男,博士,2018年以特聘副研究员引入,现为药学院硕士研究生导师。2015年毕业于苏州大学功能纳米与软物质研究院(FUNSOM),获博士学位,随后加入浙江大学药学院从事博士后研究,主要研究方向为计算机辅助药物设。迄今发表SCI论文50余篇(包括16篇第一或共同第一作者论文),论文引用总数超过1200次,担任Journal of Chemical Information and ModelingIF=3.804)青年顾问编委(ECB)。

研究方向:

1. 基于自由能计算的高精度虚拟筛选方法研究

2. 基于人工智能的个性化虚拟筛选方法研究

3. 基于动态网络的药物-靶标相互作用机制研究

联系方式

huiyongsun@cpu.edu.cn

近年五篇代表性论文:

  1. Huiyong Sun, Youyong Li, Mingyun Shen, Dan Li, Yu Kang, Tingjun Hou*,Characterizing Drug-Target Residence Time with Metadynamics: How to Achieve Dissociation Rate Efficiently without Losing Accuracy against Time-Consuming Approaches, Journal of Chemical Information and Modeling,2017, 57, 1895-1906.

  2. Huiyong Sun, Pengcheng Chen, Dan Li, Youyong Li, Tingjun Hou*, Directly Binding Rather than Induced-Fit Dominated Binding Affinity Difference in (S)- and (R)-Crizotinib Bound MTH1, Journal of Chemical Theory and Computation, 2016, 12, 851-860.

  3. Hui-Yong Sun,Ting-Jun Hou*, Hong-Yu Zhang*, Finding chemical drugs for genetic diseases, Drug Discovery Today, 2014, 19, 1836-1840.Feature article

  4. Huiyong Sun, Youyong Li, Sheng Tian, Junmei Wang, Tingjun Hou*, P-loop Conformation Governed Crizotinib Resistance in G2032R-Mutated ROS1 Tyrosine Kinase: Clues from Free Energy Landscape, PLoS Computational Biology, 2014, 10, e1003729.

  5. Huiyong Sun, Youyong Li*, Dan Li, Tingjun Hou*, Insight into Crizotinib Resistance Mechanisms Caused by Three Mutations in ALK Tyrosine Kinase using Free Energy Calculation Approaches, Journal of Chemical Information and Modeling, 2013, 53, 2376-2389.